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Document type
články
články
Document record
Source: BMČ - články
Title
Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin: Bradyarrhythmias, tachycardias, and prolonged interictal QT interval / JGR. Jefferys, A. Ashby-Lumsden, TA. Lovick,
Author
Jefferys, John G R
Department of Pharmacology, Oxford University, Oxford, UK. School of Clinical & Experimental Medicine, The University of Birmingham, Birmingham, UK. School of Biomedical Engineering, Purdue University, West Lafayette, Indiana. Department of Physiology, 2nd Medical School, Motol, Charles University, Prague, Czech Republic.

Ashby-Lumsden, Alexander
Department of Pharmacology, Oxford University, Oxford, UK. School of Clinical & Experimental Medicine, The University of Birmingham, Birmingham, UK.

Lovick, Thelma A
School of Biomedical Engineering, Purdue University, West Lafayette, Indiana. School of Physiology, Pharmacology and Neuroscience, The University of Bristol, Bristol, UK.

Cited source
Epilepsia (Copenhagen). 2020, roč. 61, č. 4, s. 798-809. ISSN: 0013-9580; 1528-1167 (elektronická verze).
Date of issue
2020
Language
angličtina
Country
Spojené státy americké
Document type
články
DOI
Grant number
James Lewis Foundation P1402 (Epilepsy Research UK)     vyhledat publikace
Pubmed ID
Link
Record number
bmc20028306
Persistent link
English Abstract
OBJECTIVE: To determine electrical changes in the heart in a chronic, nonstatus model of epilepsy. METHODS: Electrocorticography (ECoG) and electrocardiography (ECG) of nine animals (five made epileptic by intrahippocampal injection of tetanus neurotoxin (TeNT) and four controls), are monitored continuously by radiotelemetry for up to 7 weeks. RESULTS: Epileptic animals develop a median of 168 seizures, with postictal tachycardias reaching a mean of 487 beats/min and lasting a mean of 661 seconds. Ictal changes in heart rate include tachycardia and in the case of convulsive seizures, bradyarrhythmias resembling Mobitz type 1 second-degree atrioventricular block; notably the P-R interval increased before block. Postictally, the amplitude of T wave increases. Interictally, QT dependence on RR is modest and conventional QT corrections prove ineffective. Interictal QT intervals, measured at a heart rate of 400 bpm, increased from 65 to 75 ms, an increase dependent on seizure incidence over the preceding 10-14 days. SIGNIFICANCE: Repeated seizures induce a sustained tachycardia and increase in QT interval of the ECG and evoke arrhythmias including periods of atrioventricular block during Racine type 4 and 5 seizures. These changes in cardiac function may predispose to development in fatal arrhythmias and sudden death in humans with epilepsy.
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