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články
články
Document record
Source: BMČ - články
Title
Primary aldosteronism in a general population sample. The Czech post-MONICA study / J. Widimský, J. Bruthans, P. Wohlfahrt, A. Krajčoviechová, P. Šulc, A. Linhart, J. Filipovský, V. Lánská, R. Cífkova,
Author
Widimský, Jiří
Department of Medicine III, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Bruthans, Jan
Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Wohlfahrt, Peter
Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Krajčoviechová, Alena
Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Šulc, Pavel
Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Linhart, Aleš
Department of Medicine II, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Filipovský, Jan
Department of Medicine II, Faculty of Medicine, Charles University, Pilsen, Czech Republic.

Lánská, Věra
Medical Statistics Unit, Institute for Experimental and Clinical Medicine, Prague, Czech Republic.

Cifková, Renata
Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. Department of Medicine II, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Cited source
Blood pressure. 2020, roč. 29, č. 3, s. 191-198. ISSN: 0803-7051; 1651-1999 (elektronická verze).
Date of issue
2020
Language
angličtina
Country
Spojené království
Document type
články
DOI
Pubmed ID
Link
Record number
bmc20028115
Persistent link
MESH descriptor
dospělí
aldosteron (krev)
antihypertenziva (terapeutické užití)
krevní tlak (účinky léků)
průřezové studie
ženské pohlaví
lidé
hyperaldosteronismus (krev, diagnóza, epidemiologie)
hypertenze (diagnóza, farmakoterapie, epidemiologie, patofyziologie)
mužské pohlaví
lidé středního věku
renin (krev)
biologické markery (krev)
prevalence
Česká republika (epidemiologie)
Genre
English Abstract
Purpose: Primary aldosteronism (PA) is considered the most common form of secondary hypertension, however, its prevalence, particularly in a general population, is still a matter of debate. The aim of our study was to evaluate the prevalence of PA in a randomly selected general population sample.Materials and methods: A total of 1940 individuals (1% population random sample) aged 25-64 years were screened for major cardiovascular risk factors in six districts of the Czech Republic. Hypertension was defined as a mean of two blood pressure readings ≥140/90 mmHg at one visit or taking antihypertensive medication. Within this population, 740 individuals were labelled as hypertensives and 650 of them sampled for the analysis of direct plasma renin and serum aldosterone. The diagnosis of PA was based on elevated serum aldosterone, low plasma renin and high aldosterone/renin (ARR) ratio and was also verified by a confirmatory test with saline infusion.Results: Positive ARR was found in 52 (8%) individuals (64% women, 36% men, however, due to substatntial proportion of reluctatnt participants to undergo a further work-up (27%), we could confirm the diagnosis of PA only in 13 of them (2%). Aldosterone-producing adenoma was found in one case only, seven patients had idiopathic type and five individuals refused potential surgical treatment therefore, adrenal venous sampling was not performed.Conclusion: Elevated serum aldosterone together with low renin and high ARR were found in 52 (8%) of hypertensives selected from a general population sample, however, the diagnosis of PA was confirmed only in 13 of them (2%). This study based on a general population survey highlighted the difficulty of conducting epidemiological studies on primary aldosteronism in a relatively healthy cohort part of whom did not provide the level of collaboration that is necessary to assess the true prevalence of this condition.
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