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články
články
Document record
Source: BMČ - články
Title
Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors / U. Radzikowska, M. Ding, G. Tan, D. Zhakparov, Y. Peng, P. Wawrzyniak, M. Wang, S. Li, H. Morita, C. Altunbulakli, M. Reiger, AU. Neumann, N. Lunjani, C. Traidl-Hoffmann, KC. Nadeau, L. O'Mahony, C. Akdis, M. Sokolowska,
Author
Radzikowska, Urszula
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland. Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.

Ding, Mei
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland. Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Tan, Ge
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Functional Genomic Centre Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland.

Zhakparov, Damir
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Peng, Yaqi
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland. Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Wawrzyniak, Paulina
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland. Division of Clinical Chemistry and Biochemistry, University Children`s Hospital Zurich, Zurich, Switzerland. Children`s Research Center, University Children`s Hospital Zurich, Zurich, Switzerland.

Wang, Ming
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland. Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University and the Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.

Li, Shuo
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

Morita, Hideaki
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

Altunbulakli, Can
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.

Reiger, Matthias
Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.

Neumann, Avidan U
Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany. Institute of Computational Biology (ICB), Helmholtz Zentrum Munchen, Munich, Germany. Institute of Experimental Medicine (IEM), Czech Academy of Sciences, Prague, Czech Republic.

Lunjani, Nonhlanhla
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.

Traidl-Hoffmann, Claudia
Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland. Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.

Nadeau, Kari C
Sean N Parker Centre for Allergy and Asthma Research at Stanford University, Department of Medicine, Stanford University School of Medicine, Stanford, USA.

O'Mahony, Liam
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Department of Medicine and School of Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.

Akdis, Cezmi
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.

Sokolowska, Milena
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.

Cited source
Allergy (Copenhagen). 2020, roč. 75, č. 11, s. 2829-2845. ISSN: 0105-4538; 1398-9995 (elektronická verze).
Date of issue
2020
Language
angličtina
Country
Dánsko
Document type
články
DOI
Pubmed ID
Link
Record number
bmc20027656
Persistent link
MESH descriptor
angiotensin konvertující enzym 2 (genetika, imunologie)
COVID-19 (genetika, imunologie, epidemiologie)
SARS-CoV-2 (genetika, imunologie)
mladiství
dospělí
věkové faktory
staří
bronchiální astma (genetika, imunologie, epidemiologie)
dítě
předškolní dítě
chronická nemoc (epidemiologie)
ženské pohlaví
lidé
hypertenze (genetika, imunologie, epidemiologie)
přirozená imunita (imunologie)
kojenec
mužské pohlaví
lidé středního věku
obezita (genetika, imunologie, epidemiologie)
rizikové faktory
exprese genu (genetika)
komorbidita
dipeptidylpeptidasa 4 (genetika, imunologie)
chronická obstrukční plicní nemoc (genetika, imunologie, epidemiologie)
basigin (genetika, imunologie)
mladý dospělý
Genre
English Abstract
BACKGROUND: Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often reported. The range of human cells and tissues targeted by SARS-CoV-2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS-CoV-2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID-19. METHODS: We performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4+ and CD8+ T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID-19 risk factor status. RESULTS: ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age-related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147-related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147-related genes in the lesional skin of patients with atopic dermatitis. CONCLUSIONS: Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.
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