Cover & TOC
Document type
monografie
monografie
Document record
Source: katalogy Medvik
Title
WHO R&D Blueprint : novel Coronavirus : an international randomised trial of candidate vaccines against COVID-19 : 19 April 2020
Author
Date of issue
2020
Publisher
©2020
[Geneva] : World Health Organization, [2020]
Physical description
12 stran
Language
angličtina
Country
Švýcarsko
Document type
monografie
Link
Call number
NLK: online
Record number
MED00202942
Persistent link
Part of Title
Novel Coronavirus
International randomised trial of candidate vaccines against COVID-19
Abstract
This large, international, randomized controlled clinical trial is designed to enable an expeditious, agile and concurrent evaluation of the benefits and risks of multiple candidate preventive vaccines against COVID-19 at international sites with sufficient COVID-19 attack rates. Different candidate vaccines may be available or suitable to enter the trial at different times; for each candidate vaccine, the primary efficacy results are expected within 3-6 months of the vaccine entering the trial. The trial will rapidly enroll and individually randomize very large numbers of adult participants in many different populations. Each participant will be contacted weekly for information as to whether any potentially relevant symptoms have arisen, with laboratory testing triggered if the report suggests COVID-19. By using a shared placebo/control group and a common Core protocol to evaluate multiple candidate vaccines in the trial, resources allocated to the evaluation of each candidate vaccine are judiciously saved while a high standard of scientific rigor and efficiency is ensured. The trial is powered to provide sufficient evidence of safety and vaccine efficacy against COVID-19 to support decision-making about global vaccine deployment.
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